Blood viscosity and you may blood pressure level: character away from temperatures and you can hyperglycemia

Yildirim Cinar, A good. Mete Senyol, Kamber Duman, Blood viscosity and you can hypertension: part out of temperature and you may hyperglycemia, American Log from Hypertension, Volume fourteen, Thing 5, , Profiles 433–438,

Conceptual

We planned a study to research the relations among blood pressure (BP), viscosity, and temperature in healthy subjects and among BP, viscosity, and glucose in diabetics. With simple random sampling method, 53 healthy and 29 diabetes mellitus (DM) type II subjects were selected. Parameters were determined with capillary viscometer and glucometer at 22°C, 36.5°C, and 39.5°C in healthy subjects, and at 22°C on diabetic patients during OGTT with 75 g of glucose. Statistical evaluations of the data were made with regression analysis, Student t test, Spearman’s correlation, and analysis of variance. When temperature decreased from 36.5°C to 22°C, blood viscosity increased %. This increase resulted in a % decrease in blood flow rate. According to the Hagen-Poiseuille equation, the required BP increase for compensation of the resulting tissue ischemia was %. Also, a % decrease in erythrocyte deformability and % increase in plasma viscosity were seen. When temperature increased from 36.5° to 39.5°C, blood viscosity decreased %. This caused % decrease in blood flow rate, and % decrease in BP, according to the equation. Erythrocyte deformability increase of 9.92% and plasma viscosity decrease of 4.99% arose from the temperature rise. There is a correlation between total data for temperatures and viscosities (r = ?0.84, P < .001). When the mean value of blood glucose increased from 100 to 400 mg/dL, viscosity increased 25% (r = 0.59, P = .002). In this state, blood flow rate decrease was 20% and BP increase for physiological compensation was 25%. Consequently, temperature, glucose and viscosity levels of blood are important factors for BP. Am J Hypertens 2001;–438 © 2001 American Journal of Hypertension, Ltd.

The purpose of our very own research will be to research the matchmaking certainly one of heat, glucose concentration, and you may viscosity off blood and you can plasma, and also to assess its outcomes on the blood pressure levels (BP) centered on Hagen-Poiseuille’s hydrodynamics equation.

If the human circulatory system is considered as a closed system, hemodynamic equilibrium can be determined according to Poiseuille’s equation through the pressure, viscosity, flow rate, velocity of blood, and vessel diameter. Viscosity can be defined as the resistance of fluids against flow. The resistance for blood circulation includes friction between the blood elements and between the vessel lumen and blood. To make a fluid flow, the application of energy is required. Therefore, the energy of the circulatory system is spent in correlation with the viscosity level of blood. Energy forms of the circulatory system are BP and blood flow velocity. The velocity (v) and pressure of blood flow can be determined with Poiseuille’s equation as v = 1/4?L (F₁ ? F₂) (a 2 ? r 2 ), and also BP rate (Q) can be expressed from the above equation as Q = ?a 4 /8 ?L (F₁ ? F₂), where ? is the viscosity of the fluid, F₁ and F₂ are the initial and the final cross sectional pressures of blood, L is the length, a is the radius of vessel, and r is the distance from the center of the vessel for a flowing particle. 1, 2 Thus, to keep the equilibrium of the equation constant in the circulatory system, BP will increase when viscosity increases.

Bloodstream viscosity and you may blood pressure levels: part from heat and you may hyperglycemia

It’s been found you to definitely ranging from % and % philosophy off hematocrit, all the eleven% escalation in hematocrit develops bloodstream viscosity of the 20%. In this county, predicated on Poiseuille’s equation, blood circulation rate reduces of the %, which could trigger tissue ischemia. To store the circulatory program inside the equilibrium (that is, keeping the latest disperse rates sufficient and you will preventing tissues ischemia), a great 20% boost in BP otherwise 4.66% vasodilation will become necessary. step 3 not, the human being circulatory experience maybe not an accurate finalized system, because blood viscosity can be altered on the assimilation from food or medication. 4–8 While doing so, the results out-of fat molecules as well as particular medication into the bloodstream viscosity and you will hemodynamics like BP were advertised. Due to the fact atherosclerotic ships don’t dilate good enough while the a reaction to vasodilator medications, this has been suggested one to enhanced blood viscosity could only feel compensated with a beneficial BP increase in eg items. 9–several And, the brand new matchmaking one of BP, horror, coagulation, circulation velocity, and you may blood viscosity was demonstrated via the beliefs out of hemodynamics. 13, 14